Metastatic breast cancer in pituitary

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Volume 5, Number 4, Augustpages Cohen a. Pituitary metastasis is rare and unusual but can be seen in advanced breast and lung cancers with patients presenting with symptoms that range from mild headaches to seizures and altered mental status due to hyponatremia.

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Sakas, Nicolas C. Tumors metastatic to the pituitary gland are an unusual complication of systemic cancer typically seen in elderly patients with diffuse malignant disease. Breast and lung are the commonest sites of the primary tumor, whereas diabetes insipidus is the most frequent symptom at presentation.

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In breast cancer patients, the development of metastatic disease is considered to be the major cause of mortality 1. The invasion-metastasis cascade is a multistep process in which breast cancer cells invade the systemic circulation and distant tissues, and cause the metastatic colonization of different organs, including the bones, lungs and central nervous system 2. Being highly vascularized, the pituitary gland is a target structure for metastatic spread, accounting for 0.

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Pituitary metastases are rare, and unless a systemic metastatic disease is already apparent, are often preoperatively misdiagnosed as pituitary adenomas. This article will discuss metastatic lesions affecting only the pituitary gland. For other intracranial metastatic locations, please refer to the main article on intracranial metastases. The demographics of affected patients reflects that of underlying primary tumors, which are most frequently breast cancer in women and lung cancer in men; thus elderly patients are most commonly affected 1,2.

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Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Received: April 07, Published: July 18, J Cancer Prev Curr Res 8 2 :

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Metastases to the pituitary gland are rare events, and usually indicate widespread malignant disease. The lung and the breast are the most common sites of primary tumors that metastasize to the pituitary gland. Metastases are more frequent in older patients and the most common symptoms at presentation are diabetes insipidus and visual alterations.

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Metastasis from breast cancer to other parts of the body is very common, but the spread of the tumor to pituitary gland, especially to infandibulum, is a rare presentation. At the time of pituitary metastasis, a majority of the patients have clinical and radiological evidence of the disease. It seems that the posterior area of the gland is the most common site of metastasis, probably due to highly rich blood supply through the hypophyseal artery.

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Breast and lung cancers are the most common diseases that metastasize to the pituitary. Differentiation of pituitary metastasis from other pituitary tumors based on neuroimaging alone can be difficult, although certain features, such as thickening of the pituitary stalk, invasion of the cavernous sinus, and sclerosis of the surrounding sella turcica, can indicate metastasis to the pituitary gland. Overall, neurohypophysial involvement seems to be most prevalent, but breast metastases appear to have an affinity for the adenohypophysis.

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Metastatic tumors to the pituitary gland are an unusual complication typically seen in elderly patients with diffuse malignant disease. Breast and lung are the commonest sites of the primary tumor. Prognosis of patients with breast cancer metastasis is poor and depends on the primary neoplastic extension.

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Tumors that metastasize to the pituitary gland are unusual, and are typically seen in elderly patients with diffuse malignant disease. The most common metastases to the pituitary are from primary breast and lung cancers. We report a year-old woman with pituitary metastasis from breast cancer who presented with recent-onset left progressive deterioration of visual acuity and visual field.

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